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OCR: insipidus Many patients with mild cranial diabete to 4 litres) (i.e. twenty-four- hour urine volume up remain decide to have no therapy, and appear to hechanismswell. These patients rely on their thirst r reated to maintain water homeostasis. If an un hirst patient is unable to obtain fluid or loses n can be awareness (e.g. is in a coma), the conditi life-threatening. al diabetes Furthermore, long-standing severe cran insipidus can lead to hydroureter and hydronephrosis, and possibly to a degree lute nephrogenic diabetes insipidus due to so refore washout' from the kidney. There are the urinary arguments for treating all patients whos output exceeds 4 litres/24h. See later: · Vasopressin Analogues in Treatment · Nonhormonal Drugs in Cranial Diabe Insipidus Treatment